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KMID : 0882420120820060689
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Korean Journal of Medicine
2012 Volume.82 No. 6 p.689 ~ p.695
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F-FDG PET/CT in the Clinical Assessment of Patients with Multiple Myeloma: A Pilot Study
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Kim Hyun-Jung
Park Jung-Mi
Cha Jang-Gyu
Yun Jin-A
Kim Se-Hyung
Kim Chan-Kyu
Park Seong-Kyu
Hong Dae-Sik
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Abstract
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Background/Aims: This study investigated the clinical utility of positron emission tomography/computed tomography (PET/CT) for evaluating bone lesions in patients with multiple myeloma before therapy.
Methods: Whole-spine and pelvic magnetic resonance imaging (MRI) and whole-body PET/CT were conducted in patients newly diagnosed with multiple myeloma before therapy. We compared the PET/CT and MRI results for the entire spine and pelvis, and the discordance rates were cross-analyzed with the clinical factors.
Results: Ten patients were enrolled (median age 57.5 years). The majority were at an advanced stage, and IgG type multiple myeloma occurred in seven patients. All patients underwent PET/CT and 36 sites were checked on MRI. Approximately 69% of the patients had diffuse patterns, 8.3% had focal lesions, 5.6% had mixed lesions, and 16.7% had a normal pattern on MRI. The concordance rate of PET/CT compared with MRI was 83.3% (30 sites). The false-positive rate was 13.9% and the false-negative rate was 2.8%. No factor predicted the discordance between the PET/CT and MRI results.
Conclusions: A well-designed, large-scale study is warranted to confirm the accuracy of PET/CT for detecting bone lesions in these patients.
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KEYWORD
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PET/CT, MRI Multiple myeloma, PET/CT, MRI
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